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Constructive feedback about the revised PICO(T) question that addresses clarity, detail, and one other element. Evaluate the 2 research questions/hypotheses relative to their clarity, simplicity, testability.  Constructive Feedback on the Revised PICO(T) Question Essay   In elective cesarean section patients receiving spinal anesthesia, does the prophylactic use of the ondansetron reduce the incidence of hypotension and bradycardia when compared to those who did not receive ondansetron. P – Obstetrical patients undergoing elective cesarean section I – Intravenous ondansetron prior to spinal anesthesia C – Compared to those who did not receive ondansetron O – Reduced incidence of hypotension and bradycardia (cardiac instability) T - None Research question 1: What is the minimum dosing of ondansetron required to achieve cardiac stability in patients undergoing spinal anesthesia for elective cesarean sections?

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Research question 2: Does the timing of prophylactic ondansetron provide peak cardiac stability when administered to cesarean section patients undergoing spinal anesthes Constructive feedback on the revised PICO(T) question: The revised PICO(T) question is well-written and provides a clear and concise description of the study design, population, intervention, comparison, and outcomes. The inclusion criteria are specific, and the outcome measures are clearly defined. The time frame is also mentioned, which is important for determining the feasibility of the study. Overall, the question is well-structured and straightforward. One suggestion for improvement could be to include the rationale for the study, which would make the question more meaningful and relevant to the reader. Evaluate the 2 research questions/hypotheses relative to their clarity, simplicity, and testability: Research question 1: The first research question is clear and simple, and it focuses on determining the minimum effective dose of ondansetron required to achieve cardiac stability in patients undergoing spinal anesthesia for elective cesarean sections. The question is testable, and the outcome measures can be easily quantified. However, one suggestion for improvement could be to include a specific endpoint or threshold for what constitutes "cardiac stability." Research question 2: The second research question is also clear and simple, and it aims to determine whether the timing of prophylactic ondansetron administration provides peak cardiac stability in cesarean section patients undergoing spinal anesthesia. The question is testable, and the outcome measures can be quantified easily. However, one suggestion for improvement could be to specify the timing of ondansetron administration in relation to the start of spinal anesthesia.  Constructive Feedback on the Revised PICO(T) Question Essay