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You are a doctor and see a patient who has a high concentration of pyruvate in the blood and urine. One possible reason could be a gene defect in the notorious pyruvate dehydrogenase complex (PDH complex), but another explanation could be a vitamin deficiency. Explain what vitamin deficiency this could be and why it would explain the high concentration of pyruvate in the blood and urine. How would you then check which explanation is correct?
Step 1/1

ANSWER.
A thiamine (B1) deficit is one probable vitamin deficiency that could account for the elevated levels of pyruvate in the blood and urine. The PDH complex requires thiamine to be able to catalyse the reaction of oxidising pyruvate to create acetyl-CoA, just like many other biosynthetic activities in the body. Pyruvate will build up if there is not enough thiamine present because the dehydrogenase complex cannot effectively convert it into acetyl-CoA.
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Explanation for step 1

The amounts of thiamine and the different PDH complex enzymes should be measured using a variety of diagnostic techniques, including clinical profiles, blood tests, and urine tests, to determine which theory is right. This would make it easier to determine whether the problem is brought on by a thiamine deficit or a gene flaw in the PDH complex. In order to rule out any additional vitamin deficits that could possibly result in high amounts of pyruvate in the blood or urine, additional tests can also be performed to measure the levels of other vitamins.

One possible vitamin deficiency that could explain the high pyruvate levels in the patient's blood and urine is thiamine (vitamin B1) deficiency. A lack of thiamine would make PDH less efficient, which would lead to higher levels of pyruvate in the blood and urine. High Concentration of Pyruvate in the Blood and Urine Essay Example

Expert Answer

You are a doctor and see a patient who has a high concentration of pyruvate in the blood and urine. One possible reason could be a gene defect in the notorious pyruvate dehydrogenase complex (PDH complex), but another explanation could be a vitamin deficiency. Explain what vitamin deficiency this could be and why it would explain the high concentration of pyruvate in the blood and urine. How would you then check which explanation is correct?

Step 1/1

ANSWER.

A thiamine (B1) deficit is one probable vitamin deficiency that could account for the elevated levels of pyruvate in the blood and urine. The PDH complex requires thiamine to be able to catalyse the reaction of oxidising pyruvate to create acetyl-CoA, just like many other biosynthetic activities in the body. Pyruvate will build up if there is not enough thiamine present because the dehydrogenase complex cannot effectively convert it into acetyl-CoA.

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Explanation for step 1

The amounts of thiamine and the different PDH complex enzymes should be measured using a variety of diagnostic techniques, including clinical profiles, blood tests, and urine tests, to determine which theory is right. This would make it easier to determine whether the problem is brought on by a thiamine deficit or a gene flaw in the PDH complex. In order to rule out any additional vitamin deficits that could possibly result in high amounts of pyruvate in the blood or urine, additional tests can also be performed to measure the levels of other vitamins.

One possible vitamin deficiency that could explain the high pyruvate levels in the patient's blood and urine is thiamine (vitamin B1) deficiency. A lack of thiamine would make PDH less efficient, which would lead to higher levels of pyruvate in the blood and urine. High Concentration of Pyruvate in the Blood and Urine Essay Example

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